This archived forum used to be called 'Peatarian' (in reference to Ray Peat).

Feverfew as an anti-serotonin, anti-inflammatory drug?

It seems that the herb "feverfew" (Tanacetum parthenium) is a pretty potent anti-migraine supplement, with most reviews/stories I have read saying that it works well, even in some chronic cases of migraines which have not responded to painkillers.

According to studies, it seems that it has anti-serotonin, anti-prostaglandin, anti-inflammatory effects:

"Feverfew extracts are not only potent inhibitors of serotonin release from platelets but also of polymorphonuclear leukocyte granules, providing a possible connection between the claimed benefit of feverfew in migraines and arthritis..... Feverfew appears to be an inhibitor of prostaglandin synthesis. Extracts of the above-ground portions of the plant suppress prostaglandin production; leaf extracts inhibit prostaglandin production to a lesser extent." .

Has anyone here tried Feverfew? Do you notice any similarities between it and other anti-serotonin drugs, like cyproheptadine or tianeptine?
asked Apr 16, 2015 by freshness

1 Answer

Placebo-controlled trials:;2-H/abstract

Technical studies:

These studies indicate that feverfew has effects akin to aspirin, but not akin to antiserotoninergic drugs typically recommended in the peatarian sphere. Its antiserotoninergic effect rather seems to be caused by its general anti-aggregating effects. This is not to say that it is in any way inferior as such, but the effects might be more general and harder to calculate than those of other antiserotoninergic agents which poses a potential risk.
answered Apr 16, 2015 by Dewitt
So you are saying that the herb feverfew poses more of a potential risk than pharmaceutical anti-serotonin drugs (like cyproheptadine, ondansetron, tianeptine, etc)?

Have you personally tried feverfew and noticed any effects?
No, I'm saying that its risks cannot be assessed as clearly.

No, I haven't tried it.