In my own experimentation, (4 separate occasions) cynoplus induces major insomnia and anxiety, as well as a overwhelming sadness. Pregnenolone or magnesium didn't abate these symptoms.
On the other end, cynomel makes me sleep like a baby, relaxes every muscle in my body, lowers my blood pressure, and gives me a better memory. While taking about 20 mcg per day and through the night, it was the only time my wake up temp was 98.2 instead of the usual 96.8.
In all of Barnes and Peats work, the paradox of bad symptoms while taking thyroid seems to be left in the dark (when hypothyroid symptoms are present). Peat doesn't believe in adrenal fatigue and doesn't say much about panic or anxiety while barnes said less than 1 % couldn't tolerate thyroid and gave them 5mg of cortisone to supply the adrenals with enough hormone to deal with it.