This archived forum used to be called 'Peatarian' (in reference to Ray Peat). It was closed because of the behavior of Danny Roddy and his posse.

Successfully reversing grandpa's Alzheimer's

I have substantially reversed my grandfather's Alzheimer's using a Peat-influenced approach along with some of my own research/thoughts. He went from being unable to speak or get dressed to speaking, having light but continuous conversation, getting dressed on his own, remembering my name, taking showers, taking multiple walks, etc. He couldn't put his shoes on because he'd put two socks on one foot and get frustrated. The other day my grandma walked in and he had put both shoes on and tied them.

I'm currently using niacinamide, pregnenolone, magnesium threonate, gastrodin, estroban, curcumin, serrapeptase and nattokinase, along with supplemental coconut oil.

If you guys are interested in more details or the rationale behind these supplements, feel free to ask.
asked Mar 14, 2015 by QiGuy1997
edited Mar 14, 2015 by QiGuy1997
"I'm currently using niacinamide, pregnenolone, magnesium thereonate, gastrodin, estroban, curcumin, serrapeptase and nattokinase, along with supplemental coconut oil."

How can you honestly attribute success to Peat's diet and supplements when you are also using supplements like the enzymes and curcumin. That is very dishonest of you.
Did you read my post? "peat-influenced approach along with some of my own research/thoughts". There was NO dishonesty here, I perfectly described the role that Peat's work played in this protocol. And I do not recall even mentioning Peat's diet.
No vitamin E or aspirin?
There is viramin E in the estroban and no aspirin, the nattokinase is already thinning his blood to the degree that he bruises easily.
Are you considering the use of low dose methylene blue orally or as Ray takes it topically ?
He was on SSRIs when I started and methylene blue can dangerously interact with SSRIs, causing serotonin syndrome. Now that he's off of them, I'm considering it. I think curcumin acts in many ways similar to methylene blue though.
Increased neurogenesis, improved mitochondrial respiration, inhibits nitric oxide production/quenches related free radicals, etc.
The methylene blue is something that many self-experimenters have discovered. It's surprised me with the way it improves reaction times even in doses of a milligram or less. Can you measure his reaction times, if he has a computer online?
http://www.bbc.co.uk/science/humanbody/sleep/sheep/reaction_version5.swf
http://www.humanbenchmark.com/tests/reactiontime

Less well known is urea, if your grandpa's kidneys are ok? Peat has said that very old people who are healthy might use increased urea levels to balance their higher levels of water and salt.

Urea was also known to improve brain edema before the pharma dark ages befell us, and displaced much of what we knew.

One more thing is to try to monitor his sleep cycles, for example, with a Basis watch.
https://store.mybasis.com/
The lack of slow wave sleep is what Peat thinks prevents the brain and body from regenerating. Especially if you're not there, it helps you to see how he's doing day-to-day.

(I'm leaving out CO2 therapy, since I think it would be hard for him to do unless you were there.)
First of all, my sympathies. But second, well done for what you've achieved.
QiGuy1997 , I sent you a private message with some questions ...
Wisteria, Where does Ray say he uses MB topically?
In this interview he mentioned that he is currently using it topically http://www.raypeatforum.com/forum/download/file.php?id=1045
please keep us updated :)

I would suggest light therapy as an addition, but you said he is taking multiple walks which is extremely important in his state (increase in CO2 & light exposure & stimulation) and covers this to an extend.
Last summer a magazine in my local published an article about a physician that seems to think thyroid is the best treatment for alzheimers and reports success with it. But I think you may have a more nuanced/better approach and I'm stoked to hear it's working.

4 Answers

This might be the coolest post I have seen.  *Virtual high five.  Any CO2 therapy/supplementation or thyroid being used?
answered Mar 14, 2015 by Zach Shane
No, no thyroid because I think that Alzheimer's is characterized by extremely scarce brain glycogen and I think thyroid may speed it's depletion. While thyroid is important, I'm trying to principally quiet activity, not activate anything for now at least. That's also why I restrict him to one cup of coffee with a lot of orange juice.
Besides, alzheimer's causes the neurons to become profoundly insulin resistant because tau and beta amyloid plaques destroy insulin signaling and PDH activity. I don't think additional thyroid stimulation would do much for cells which cannot physically take in glucose.
Does curcumin act on tau proteins tangles the way MB is thought to?
Yes, it lowers Tau proteins and beta-amyloid plaque.
Nice.

I'm curious about the Nattokinase, what's the rational there?

Also wondered if you'd considered thiamine?
I haven't looked much into thiamine. Recent literature suggests that nattokinase and serrapeptase dissolve beta amyloid and tau plaques and down regulate many components of brain inflammation like tnf alpha and IL6. I would nit be surprised if they reduce nitric oxide as well.
Thanks. All very good to know!
Curious if T3 would increase the demand on the brains glycogen or actually increase the ability to store glycogen in the brain, removing some reverse t3 on the receptors.
I think quite a number of self-experiments have shown you can reverse dementia and Alzheimers, if not completely cure it. Peat's ideas about the science of metabolic stress and regeneration are really at the core of all of them.

The problem I see is getting past the inevitably incompetent medical care and diet and drugs that are the cause of the dementia or Alzheimers in the first place.

Does your grandfather ignore what his doctor says, and not eat what the doctor tells him and not take his prescribed drugs?

Or does he happen to be someone who is appropriately skeptical of doctors and their prescriptions for diet and drugs?
answered Mar 14, 2015 by visionofstrength
He tried all the drugs (Alzheimer's medications, SSRIs) and when they failed to improve anything and only caused intolerable side effects, my grandma took him off everything and told me she'd give him whatever I sent them. The only medication he is left on is one for prostitis.
They must think a lot of you. I'd say it's rare in my experience, unfortunately, for families to have such faith in each other, and not be swayed by media and doctors.

I hope willingness to resist coercion runs in your line (and at least from your posts here, it seems it does). Mankind needs that right now.
This is great news, QiGuy1997
Thanks for sharing your approach! Could you give us some more information so we can make a better interpretation of your results?

 - What doses and daily schedules for each of the molecules do you use?
 - What timeframe are we speaking about in which his cognitive state has improved? Did you start all things at once or slowly introduced one after the other? Did you take notes when most of the improvements came, to distinguish which molecules you use are helpful and which are not?
 - Did you objectivify the improvements with some basic cognitive tests, e.g. the MOCA-Test (www.mocatest.org). The test can be done within 10 minutes and on the homepage youll find instructions on how to do it with different test versions included.
 - What was his full medication list prior to the experiment and could his improvements be merely a consequence of getting of SSRIs and (potentially) other problematic drugs?
answered Mar 15, 2015 by Bukowski
The effects began to appear almost immediately. Within three days or so, which I attribute probably to the niacinamide and pregnenolone the most. However, within the past three weeks, the condition is continuously improving as he's recapturing more old skills such as him relearning to tie his shoes this week. I introduced thinds two at a time. The most immediate effects were seen with the introduction of the preg and the niacinamide. The others act more long-term on the plaques and things. I did not perform any objective test because he lives in another state and my grandma is not very skilled at using computers. He does have images of his brain so I'm hoping to eventually get more and compare the before and after a few months of treatment. His full medication prior to this experiment was an SSRI, a medication for prostitis and Benadryl. He is still taking the Benadryl and the prostrate medication. The improvement came before he got off of the SSRIs. He'd been taking SSRIs with no benefit. I introduced the supplements and he improved quickly. After that point, my grandma took him off the SSRIs because they always gave him intestinal distress and she didn't think he needed it after the improvement.
Thats great to hear. What doses of niacinamide and pregnenolone does he take?

Btw for the test, you dont need to use a computer, its a single page that you print out and fill together with the patient, the instructions are a couple more print pages.
Qiguy, if you ever have the time/inclination to post dosages for all or any of these supplements, I would appreciate it as well.  Thanks.
What about progesterone?
answered Mar 19, 2015 by freshness
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