What do you guys think of this product, it cost about 80$ that will last you a little over a year.
There's nothing "Primal" about something that contains DMSO and isopropanol as a first ingredients and it's also not the way "nature intended" to have vitamin D delivered together with such substances.
Leaving marketing claims aside, what do you think of the science? http://primal-d.com/docs/Primal-D%20Topical%20Vitamin%20D%20r1.5.pdf
The idea seems to be that DMSO and isopropanol can improve delivery through the skin, if oral delivery is not effective.
Just more marketing talk in there with lots of claims based on low-quality science. There's even overtly false information in there: Check out figure 3 where they claim that oral vitamin D supplementation doesnt increase vitamin D in the referenced study. In that study there was no oral control group, only a vehicle control group that was (knowingly or unkowningly) mislabelled by the marketers as the oral group. That referenced study btw also comes along as marketing their patented aloe vera product.
They didnt provide any study on the long-term safety of topical DMSO or isopropanol, nor did they provide evidence that topical vitamin D has the same or better effect than oral supplementation.
Good points! Yes, it's more of a narrative about the pathways of D3 through the skin. Myself, I can't hold all small startup products to the delay and expense of phase II trials that should be (but are not) rigorously required for designer pharma drugs.
I think of D3, DMSO and alchohol as open source molecules that have been used on the skin with whatever results they've had, or not had. For example, I often experiment with DMSO and ethanol as a base, but I've never thought of using it for D3.
So for those (like me) who may want to raise D3 when oral supplements and even sun don't work, it could be worth experimenting, even if by mixing one's own D3 and base?
What about just applying D3 in MCT oil? Shouldnt that be enough as a carrier through the skin?
Hah! I've never tried MCT oil as a carrier! Is it a good carrier? (or why, if you know?) That would be great!
There are a couple of oral supplements that contain just D3 and MCT oil. I have one product from Merck standing here, I occasionally use it topically.
Yes, I see that at least in babies, some of the saturated fats seem to penetrate the skin.
I wonder how much of the Vit. D would be carried through the skin with the MCT? Seems like some should be, since it's dissolved, and a fairly small molecular weight?
What would be the problem with a bit of rubbing alcohol?
I remember Ray Peat saying he was using topical vitamin D (Carlson's) so I guess it is a good product if it has no toxic eccipients. The price seems crazy, btw.