I wrote about this last September, and was shouted down in the raypeatforum for being a fattist. Now it has 7500 shares on Facebook, and even a share here.
Things to think about: A controlled release generally is the same as taking divided doses throughout the day.
Coffee has the same effect of uncoupling if the appropriate dose can be found, which may be different for each person.
I would suggest everyone try uncoupling, if only to experience it. It's the same effect you get (high CO2) when climbing at very high altitude.