This archived forum used to be called 'Peatarian' (in reference to Ray Peat). It was closed because of the behavior of Danny Roddy and his posse.

Turmeric: Peat or not Peat

Well. I had an extremely long post with about 50 studies about turmeric/curcumin until my IPad refreshed and deleted it. However, I will not give up! I am, though, going to summarize what I had in my previous post and I can provide the specific references if you guys are interested. Here it goes.

Turmeric is a Indian spice with numerous reputed health benefits. Studies have confirmed most of these benefits. It has been shown to be powerfully anti-inflammatory (through a variety of mechanisms, Nf kappa beta, cox-2, etc), neuro-protective, protective against Alzheimer's and Parkinson's disease and protective of mitochondria. It also seems to oppose estrogen, increase insulin sensitivity, improve glucose homeostasis, defend against cancer, activate detoxification pathways, increase brain neurogenesis and neuroplasticity through upregulated Brain Derived Neurotrophic Factor, act as an anti-oxidant, reduce lipid peroxides, increase glutathione levels, reduce expression of Nitric Oxide Synthase and neutralize existing nitric oxide radicals. Furthermore, studies have round that it is profoundly anti-depressant (as in as effective as Prozac without the side effects). It reduces the period of immobility caused in rats after the stress-swimming test and increases concentration of dopamine and noradrenaline in rats which have had it lowered from chronic stress.
All of these effects are very pro-Peat, are they not? One problem, however, is in the same studies that showed reduced period of immobility (learned helplessness), reduced stress and increased dopamine/noradrenaline also showed increased brain concentrations of serotonin. How is this possible? I thought serotonin promoted depression/inflammation but here, a strongly anti-inflammatory and anti-depressant herb which fights learned helplessness actually increases serotonin? I'm very confused. Any thoughts would be greatly appreciated!

asked Mar 13, 2014 by QiGuy1997

Apparently tumeric, while purportedly having many benefits, also contains some strong toxic substances. I had some this morning and have felt tired and groggy all day. I think it should be used on an individual basis.

Serotonin is a stress hormone, and like estrogen, can produce a false sense of euphoria when elevated. Long-term that effect will wear off. Similar to how SSRI's are not effective, but actually counter-productive, long term in depressed individuals.

4 Answers

Ray Peat is not pro-spicy, it's up to you if you want to use it or not.

answered Mar 13, 2014 by Health
edited Mar 13, 2014 by Health

turmeric is a relatively versatile and universal medicine for most things. Just like any medicine, bitter, or herbal substance it comes with side effects or can be overdone...either at once or over time. Its has slightly anti-inflammatory properties, meaning it can help lessen pain, pressure, and high stress...it also helps bulk stool, and cough up and loosen phlegm. However, for me, its kind of rough and can lead to that typical 'yellow liver' style effect, similar to any other detoxifying but intense or liver demanding substance. A dry feeling, in the skin, saliva, eyes...and perhaps even some burning in the gut, and it doesn't always pass comfortably. If it was all I could get or had in certain places or situations, I might use some...but because other herbs with similar properties are available, I tend to pretty much never use turmeric

answered Mar 13, 2014 by pboy

I think I heard Peat in a radio show (can't remember which, sorry) say that curcumin chelates iron and aids in its removal from the brain and other tissues, which is why it's protective against degenerative brain disease, (I guess this may be a reason why Alzheimer's is rare in India).

answered Mar 13, 2014 by samtaylor

Ya, it does.Plus it increases BDNF and increases brain removal of amyloid plaques.

I just took a few capsules.  I might feel a little strange, not sure.  Thanks for the info.

Is serotonin really so bad?  Indians use turmeric daily.  They seem OK.
answered Apr 6, 2015 by darth mall
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