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How to Increase DHT

+1 vote
What specifically and generally can increase 5-AR to increase DHT? Also, what can be antagonistic to it?
asked May 17, 2012 by anonymous
recategorized May 17, 2012 by Bruno
  

1 Answer

+2 votes
I asked this question before. Peat said "Avoiding PUFA, having lots of fruit, some liver for vitamin A, and supplementing thyroid if it's needed."

 

A very general answer, and there is a reason for that. There really isn't much specificity, in terms of hormone modulation in nature. You can't just increase DHT, without increasing, or modulating testosterone, progesterone, and other hormones. When the whole body changes, DHT changes, but it doesn't happen the other way around, unless you are taking exogenous DHT, which I don't recommend, because it will shut your HPTA down. But, HRT docs are finding that DHT is far more effective than testosterone for men with impotence, and other hormonal issues. I guess its because it can't be aromatized and it is a potent saturated androgen.
answered May 26, 2012 by stevensmith
Thanks for the reply. What I had in my mind was that coconut oil (lauric acid) may be a 5-AR inhibitor.

I understand we can't directly control hormones. But if there is a component of the Peat inspired diet that can have an anti-androgenic effect, I'd want to reduce it if other foods can offer similar benefits without the drawbacks.
The evidence I have seen referencing free fatty acids to 5aR inhibition is here:
http://www.sciencedirect.com/science/article/pii/S0960076002001875

The Journal of Steroid Biochemistry and Molecular Biology, Oct 2002, 82(2-3):233-239, "Inhibition of type 1 and type 2 5?-reductase activity by free fatty acids, active ingredients of Permixon"

And notice closely, that they are referring specifically to free fatty acids, not lauric acid per se. Remember that there are many things that are supposed "5aR inhibitors" even vitamin D, and the potent antiestrogenic vitamin E. Even high protein diets have been shown to lower 5aR activity. But do all these studies make sense? Depends on the circumstances. But I do know that for many of them (not technically including the ones mentioned above) are from free living studies, not controlled, which means nothing in the world of science, and nothing to us. So lying about how much protein one eats constitutes sound science? Hardly....

Remember that many foods such as beef fat, and milk are also very high in lauric acid. Are you going to cut those out too?

Seems that the only sound evidence, is that free fatty acids lower 5aR activity, which isn't much of a surprise. Free fatty acids, circulating in the blood stream also deplete thyroid function, and circulating free fatty acids is  the very thing Dr. Peat is against. Coconut oil hardly encourages free fatty acid formation in vivo, and is largely responsible for ketone formation, and of the short and medium chain triglycerides, not free fatty acids. Free fatty acids will be a huge factor in anyone on a low carb diet, as they are being released from the tissue when the body is glycogen depleted. But when the body runs mostly on sugar, this doesn't happen. Dr. Peat never said that coconut oil HAD to be in the diet. Certainly if it worries you, you could reduce it or cut it out completely, but it is unnecessary. Peat believes that there are no essential fats, and that we can subsist on mostly low fat foods.

Coconut oil could probably increase DHT in context, because of the strong anti-endotoxin and antibiotic effect of Lauric acid, which will decrease serotonin formation and estrogen thus increasing testosterone, and DHT down the line.
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