This archived forum used to be called 'Peatarian' (in reference to Ray Peat).

Low Dose Naltrexone for autoimmune diseases, boosting immune function?

Anyone tried Low Dose Naltrexone? It appears it could be beneficial for those with Hashimotos:

Ive just stumbled upon it tonight. Some quick cut and pasting:

Chris Kresser:
"I would highly recommend learning more about low dose naltrexone (LDN). It is a new, very promising treatment for MS and other autoimmune conditions."

Paul Jaminet regarding chronic infections:
"Also, you could consider therapies like low-dose naltrexone."

"Many Hashimoto’s thyroid patients are using LDN to reduce their stubbornly high antibodies."

"Some claim that LDN has fixed their fibromyalgia or brain fog."

"LDN may lead to a prompt decrease in the autoimmune disorder, which then may require a rapid reduction in the dose of thyroid hormone replacement in order to avoid symptoms of hyperthyroidism."

asked Sep 30, 2013 by Peato Diet

please excuse my ignorance, but what's the difference between Hashimoto's and Hypothyroidism? Does one cause the other? Or is Hashimoto's an extreme hypothyroidism?

@lecomer: Chris Kresser provides a good overview of the thyroid in laymans terms. Basically if you have hypothyroidism then there's a 90% chance its hashimoto's ie your body is having an autoimmune reaction to something. The resulting antibodies attack/destroy the thyroid thus low levels of thyroid hormone. So for 90% of hypos out there the issue isnt necessarily PUFA etc eg it could be a leaky gut which as i understand can be a huge source of autoimmune reactions:

Im guessing my doc wont prescribe LDN (here in the UK). It is only available online in 50mg tablets, however the recommended dose is approx 3mg. Anyone know how to administer a 3mg dose from a 50mg tablet. Can it be dissolved in alcohol or vodka? Will it remain stable for approx 20 days if dissolved in vodka?

3 Answers

Is anyone else taking LDN or have updates on their progress?

Also where do you order it online? (I need to ship to Canada)

answered Dec 30, 2013 by ilovethesea

Naltrexone is sold under the following names:
Antaxon, Antaxone, Basinal, Celupan, Depade, Dependex, Destoxican, Ethylex, Nalerona, Nalorex, Naltax, Naltima, Naltrax, Naltrekson, Naltrexin, Naltrexon, Naltrexona, Naltrexonum, Narcoral, Nemexin, Nodict, Opizone, Revez, Vivitrol


They come as 50mg tablets. Dose is 4.5mg. You therefore need to dissolve a 50mg tablet in 50ml of distilled water so that 4.5ml provides 4.5mg. Use syringe to measure.

Ive been taking it for about 3 weeks now in the hope it will help with brain fog which i suspect is an autoimmune reaction to something im eating or leaky gut. I dont think it has had any effect yet but apparently it can take months. Its very cheap so no strain on the finances.

I been taking 2mg Liquid LDN..... not sure i notice much difference but i only been on it for a few months now (did stop a little)
read it can take up to 1 year for people to start noticing real benefits.. so i'll try it for a year

answered Sep 30, 2013 by animal

Interesting.. I have Hashimotos and I would really love to see more answers and opinions here

answered Oct 1, 2013 by Nemesis