This archived forum used to be called 'Peatarian' (in reference to Ray Peat).

23Andme Test

thinking about this test, its only $99, seems good on genetics testing

what you think ?

asked May 19, 2013 by animal
It was very much worth it to me, I made two major lifestyle changes based on the information I received.

(1) I started drinking milk because I discovered I'm not lactose intolerant (my parents had told me I was), and (2) I pushed all my caffeine intake into just after waking because I'm a slow caffeine metabolizer- and now I can sleep better.
I thought Peat was against the idea of genetics.  ?  

I figured out my genotype in 2011; for a while it helped me but ultimately did not solve my metabolic problems.  I'm a pure paleo DNA type (Hunter/Gatherer) which means fast aging, fat gain, and thyroid problems.  Paleo makes it worse, not better:
I'm not sure what you mean but I really doubt Ray Peat, as a biologist would be "against the idea of genetics." Genetics is responsible for much of the basic biological knowledge his ideas are built upon.

The "genotype diet" is fraudulent, it has no supporting scientific evidence. Something like that might be possible in the distant future, but we don't yet have enough understanding of human genetics to individualize diet beyond a few basic things- such as predicting lactase persistence/lactose tolerance.
bioassay, Peat would be against the idea of genetics being a hard-wired fact.

You might be able to tolerate lactose just fine despite being "genetically-lactose-intolerant" or vice versa(due to bacterial overgrowth for example).

Or someone with a low metabolism may not be able to tolerate caffeine even though they're "fast caffeine metabolizers".
Agreed, It's a popular misconception (spread via poorly written news articles as far as I can tell) that genetics somehow hard-codes your fate independently of your environment.

However, I don't think there's much controversy about that issue amongst geneticists- it's well understood that your "fate" (i.e. phenotype) is determined by complex interaction between your genome and your environment. While it doesn't set your fate, your genome will heavily influence how your body will react to a given environment.

The output from 23andme is well designed, and doesn't fall victim to this misconception. It shows how knowledge about a specific mutation modifies your risk probability for a given trait or disease. For example, a given mutation might double your probability of developing macular degeneration- however you'd combine that with all of your existing knowledge (prior information including family history and your personal dietary practices) to calculate your actual probability.

Edit: Note that "probability" in this context refers to the state of your current knowledge level, not an actual property of the processes going on in your body.

2 Answers

It's cool but pretty much a novelty item, I can't see it being that useful medically but if you're interested in genetics or genealogy it's definitely worth it. Let us know your Neanderthal admixture.

answered May 19, 2013 by Lemonhead

The HairDX Genetic Test predicts your risk for hair loss or thinning

this looks more "serious" than 23andme because of its science references

answered May 21, 2013 by Pafi